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Premier Neuropsychiatry in the Montrose/Museum District area.
Expert Care, Personalized Approach

Michael D Lesem, MD PA is a leading outpatient psychiatry office spearheaded by Dr. Michael Lesem, a seasoned psychiatrist with specialized expertise in psychopharmacology and clinical trials. Our clinic is dedicated to offering top-notch medication management, cutting-edge Spravato (Esketamine) treatment, and comprehensive ADHD evaluation services, ensuring tailored care and optimal outcomes for every patient.
Services Provided
Spravato® (esketamine) treatment in Houston, TX offers a breakthrough option for adults struggling with treatment-resistant depression when traditional antidepressant medications have failed. Our psychiatric clinic provides personalized, medically supervised Spravato therapy in a comfortable clinical environment with same-week availability and comprehensive insurance coordination.
Spravato is FDA-approved for individuals who have not responded adequately to at least two antidepressant trials. As a leading Spravato clinic in Houston, our board-certified psychiatric team combines evidence-based care with meticulous medical monitoring to ensure each treatment session meets the highest safety standards.
What Is Spravato (Esketamine) Therapy?
Spravato is a nasal spray form of esketamine administered under direct medical supervision. Unlike daily oral antidepressants, Spravato rapidly targets glutamate signaling in the brain, providing symptom relief often within days rather than weeks. Sessions take place in our Houston clinic with a two-hour observation period as required by FDA REMS safety guidelines.
Who Qualifies for Spravato in Houston?
Candidates for Spravato therapy typically meet the following criteria:
• Diagnosis of major depressive disorder
• Failure to respond to at least two antidepressant medications
• No uncontrolled hypertension or unstable medical conditions
• Ability to attend monitored in-clinic treatments
Our team conducts comprehensive psychiatric evaluations to determine eligibility safely and responsibly.
Insurance Coverage for Spravato Treatment
Most major insurance plans cover Spravato therapy when clinical criteria are met. We routinely work with:
• Medicare
• United Healthcare
• Blue Cross Blue Shield of Texas
• Aetna
• Cigna / Evernorth
Our staff manages benefits verification, prior authorizations, and RETMs compliance so patients can focus solely on recovery.
Our Houston Spravato Clinic
We proudly serve patients across greater Houston including:
• Memorial & Galleria area
• Katy
• Sugar Land
• Midtown Houston
• The Woodlands
Our centrally located clinic offers private monitoring rooms, continuous staff supervision, and licensed psychiatric providers experienced in esketamine administration protocols.
Why Choose Our Spravato Treatment Center?
✅ Board-certified psychiatric supervision
✅ Full REMS compliance & safety monitoring
✅ Same-week scheduling available
✅ Insurance acceptance and benefits coordination
✅ Compassionate, discreet clinical environment